Presage Biosciences is an oncology company that is pioneering an entirely novel approach to evaluating patient response to drugs in clinical trials.
Our Team and Board
Nathan Caffo is a life sciences professional whose 23-year industry career has been focused on personalized medicine and applications of genomic technology. Before joining Presage as its first employee in 2009, he consulted for a UK-based diagnostic company, Curidium Medica, and led the efforts to identify an acquirer for that business.
Mr. Caffo also led drug in-licensing at Perlegen Sciences, a genomic medicine spin-off of Affymetrix. Prior to that, he worked at Applied Biosystems (now Life Technologies) and its sister company Celera (now Quest Diagnostics) for 11 years in a number of technical and business roles, including managing the company’s genomics service business. Mr. Caffo has a B.S. in Microbiology from Pennsylvania State University.
Richard Klinghoffer, Ph.D.
Richard Klinghoffer brings 20 years of research, drug development and team leadership experience to Presage. His team established the Presage platform, CIVO™, which enables multiplexed drug efficacy studies in both in vivo preclinical models of cancer and the human oncology clinic. Before joining Presage, Dr. Klinghoffer worked in both small biotech and large pharma settings, most recently at Merck’s Rosetta Inpharmatics. At Rosetta, he led a team of scientists focused on identifying and validating cancer targets and predictive biomarkers of novel chemotherapeutics for Merck’s Oncology Franchise. Dr. Klinghoffer earned his Ph.D. from the University of Colorado Health Sciences Center and was a Special Fellow of the Leukemia and Lymphoma Society as a Postdoctoral Fellow at the Fred Hutchinson Cancer Research Center.
John Streeter brings 23 years of medical device experience with a successful track record of novel product development, first human use and early commercialization. Prior to joining Presage, he led an advanced team of engineers and scientists in novel delivery device conception and development for L’Oreal. As the first employee and VP of R&D for Holaira (now Nuvaira), he led development and early operations efforts for a novel COPD therapy device. John has led teams introducing a broad variety of innovative products including cardiovascular, gastrointestinal, pulmonary and orthopedic devices. He has held departmental management positions with large and small companies including Cerapedics, EndoGastric Solutions and WL Gore & Associates. John holds a degree in Chemical Engineering from the University of Colorado.
Christoph Lengauer, Ph.D., MBA
Christopher Lengauer is the Chief Scientific Officer of Blueprint Medicines, a public personalized medicine company. Dr. Lengauer has a proven track record in cancer drug discovery, including contributing to 13 programs that reached first-in-human clinical trials and three registered drugs. He was previously at Sanofi, where he was Vice President and Global Head of Oncology Drug Discovery and Preclinical Development. Before joining Sanofi, he was Executive Director & Senior Unit Head, Oncology Discovery at the Novartis Institutes for Biomedical Research. Prior to Novartis, Dr. Lengauer served as associate professor of oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University. Dr. Lengauer studied human genetics in Salzburg, Austria, and obtained his Ph.D. from the University of Heidelberg, Germany. He did his postdoctoral research at the Research Institute of Molecular Pathology (IMP) in Vienna and then in the laboratory of Profs. Bert Vogelstein and Ken Kinzler at the Johns Hopkins University School of Medicine. He received his MBA from Johns Hopkins University Business School.
David Johnson brings more than 25 years of experience in the biopharmaceutical industry. His most recent executive position was with Acerta Pharma, an oncology-focused pharmaceutical company, where he was CEO and led the company through a critical phase of growth from approximately 40 to 150+ employees and from signal seeking first-in-human trials to more than 20 active clinical studies. His tenure included the launch of two global Phase 3 trials and culminated in the execution of a strategic transaction with AstraZeneca valued at up to $7 billion. Mr. Johnson’s prior experience spans from pre-clinical to all phases of clinical development. He has made meaningful contributions to drugs ultimately garnering NDA/SNDA approval including idelalisib, romidepsin, and bortezomib. He has held roles with increasing responsibilities within Clinical Development, Medical Affairs, Pipeline Development, and Commercial at companies including Calistoga (acquired by Gilead), Gloucester (acquired by Celgene), Favrille, Millennium, Immunex (acquired by Amgen), and Hoffman La Roche. Mr. Johnson is a proven leader, deeply-rooted in oncology with a long track record as a successful collaborator with a broad global network of investigators. He is a co-author on numerous publications including three NEJM publications. Mr. Johnson is a graduate of Indiana University.
An accomplished entrepreneur in the life sciences industry, Brad Margus has co-founded and led several life sciences companies, most recently founding Cerevance, Inc., a new drug discovery company. Prior to Cerevance, Mr. Margus started Genome Bridge, a non-profit subsidiary of the Broad Institute of Harvard and M.I.T., to build a computational platform for sharing genomic and clinical data. Previously, as co-founder and CEO of Envoy Therapeutics, Mr. Margus raised $8 million from investors, discovered new compounds for brain diseases, and sold the company to a global pharmaceutical company for $140 million. Earlier, he was co-founder and served as CEO of Perlegen Sciences, a leader in analyzing genetic variation. Concurrent with his business career, for the last 20 years, Mr. Margus has worked as founder and volunteer President of the A-T Children’s Project, a non-profit that orchestrates research on a rare, brutal, genetic disease – ataxia telangiectasia or “A-T” – that two of his sons have. A-T causes neurodegeneration, cancer and immune system problems. Mr. Margus co-chairs the Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT) External Oversight Board at the National Institutes of Health. He also serves on the Steering Committee for the Global Alliance for Genomics & Health and on the Board of Global Genes.
James Olson, M.D., Ph.D.
Jim Olson is a pediatric oncologist practicing at Seattle Children’s Hospital and an Associate Member of the Fred Hutchinson Cancer Research Center. Dr. Olson’s laboratory studies the gene expression programs controlling neural differentiation, brain tumor genesis and neurodegenerative diseases. His team has conducted laboratory research that led to five national clinical trials for children with brain tumors. Dr. Olson trained at the University of Michigan School of Medicine and Department of Pharmacology.
Tachi Yamada, M.D.
Tachi Yamada, M.D. recently led all of Takeda’s research and development activities as the Chief Medical and Scientific Officer. He is currently a venture partner with Frazier Healthcare in Seattle. Prior to Takeda he was the President of the Global Health Program at the Bill & Melinda Gates Foundation. He also served as the Chairman of Research and Development and was a member of the board of directors at GlaxoSmithKline. Earlier, Dr. Yamada was the Chief of the Division of Gastroenterology and the Chair of the Department of Internal Medicine at the University of Michigan in Ann Arbor. In addition to his current role at Frazier and Presage, Dr. Yamada serves as a member of the board of directors at the Clinton Health Access Initiative and a member of the Council of the National Academy of Medicine. He is also a Fellow of the Imperial College of Medicine, a Master of the American College of Physicians, a Fellow of the Royal College of Physicians, and a past-President of the American Gastroenterological Association and the Association of American Physicians.